Background: Alcohol use disorder (AUD) and its associated consequences remain
significant public health concerns. Given that AUD represents a spectrum of severity …

There is substantial interest in the therapeutic potential of cannabidiol (CBD), a
nonpsychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current …

Background The rate of participant attrition in alcohol clinical trials is often substantial and
can cause significant issues with regard to the handling of missing data in statistical …

Importance No medication has been established as an efficacious treatment for cocaine
dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine …

Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual,
5th Edition (DSM–5), is a heterogeneous disorder stemming from a complex interaction of …

Research on the concept of craving may lead to better understanding of the biobehavioural
circuitries that contribute to the complexity of alcohol use disorders (AUDs). The experiences …

Background The course of posttraumatic stress disorder (PTSD) is frequently and severely
complicated by co‐occurring alcohol use disorder (AUD), yet there are few reports of …

Alcoholic patients suffer from harmful allostatic neuroplastic changes in the brain causing an
acute withdrawal syndrome upon cessation of drinking followed by a protracted abstinence …

The anticonvulsant topiramate not only decreases ethanol consumption in alcohol
dependence (AD) but also may produce several adverse events including cognitive …

Background Alcohol dependence is a major public health problem that is characterised by
recidivism and a host of medical and psychosocial complications. Besides psychosocial …