Early intra-abdominal bacterial infections after orthotopic liver transplantation: a narrative review for clinicians

R Taddei, N Riccardi, G Tiseo, V Galfo, G Biancofiore - Antibiotics, 2023 - mdpi.com
Despite recent advances in the transplant field, infectious complications after orthotopic liver
transplantation (OLT) are major causes of morbidity and mortality. Bacterial intra-abdominal …

Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades

DR Giacobbe, V Di Pilato, I Karaiskos, T Giani… - Annals of …, 2023 - Taylor & Francis
Antimicrobial resistance is a global health threat. Among Gram-negative bacteria, resistance
to carbapenems, a class of β-lactam antibiotics, is usually a proxy for difficult-to-treat …

Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination and evolution of a major clinical challenge

V Di Pilato, S Pollini, V Miriagou… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Klebsiella pneumoniae is a major agent of healthcare-associated infections and
a cause of some community-acquired infections, including severe bacteremic infections …

Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediating resistance to avibactam-based β-lactamase inhibitor combinations and cefiderocol

V Di Pilato, G Codda, C Niccolai, E Willison… - International Journal of …, 2024 - Elsevier
Objectives To investigate a ceftazidime/avibactam (CZA)-resistant Klebsiella pneumoniae
(NE368), isolated from a patient exposed to CZA, expressing a novel K. pneumoniae …

[HTML][HTML] Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae: analysis of cases and evaluation of in vitro activity of …

A Oliva, D Al Ismail, G Arcari, MC Miele, E Casali… - Journal of Global …, 2023 - Elsevier
Objectives Little is known regarding outcomes and optimal therapeutic regimens of
infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella …

Prevalence and impact on mortality of colonization and super-infection by carbapenem-resistant Gram-negative organisms in COVID-19 hospitalized patients

R Casale, G Bianco, P Bastos, S Comini, S Corcione… - Viruses, 2023 - mdpi.com
Background: The relationship between superinfection by multidrug-resistant Gram-negative
bacteria and mortality among SARS-CoV-2 hospitalized patients is still unclear …

Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of blaKPC …

M Al-Muzahmi, M Rizvi, M Al-Quraini, Z Al-Muharrmi… - Microorganisms, 2023 - mdpi.com
Conjugative transposons in Gram-negative bacteria have a significant role in the
dissemination of antibiotic-resistance-conferring genes between bacteria. This study aims to …

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis

S Shen, C Tang, W Yang, L Ding, R Han… - Emerging Microbes & …, 2024 - Taylor & Francis
Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by
Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to …

Clinical Characteristics and Outcome of Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae Carbapenemase–Producing Klebsiella pneumoniae Infections: A …

A Oliva, L Campogiani, G Savelloni… - Open Forum …, 2023 - academic.oup.com
Abstract Background Recently, Klebsiella pneumoniae carbapenemase (KPC)–producing
Klebsiella pneumoniae (KPC-Kp) with resistance to ceftazidime/avibactam (CZA-R) has …

[HTML][HTML] Activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against isogenic strains of Escherichia coli expressing single and double β …

T Blanco-Martín, I Alonso-García… - International Journal of …, 2024 - Elsevier
Objectives To analyse the impact of the most clinically relevant β-lactamases and their
interplay with low outer membrane permeability on the activity of cefiderocol …