Meiosis is a critical cell division program that produces haploid gametes for sexual
reproduction. Abnormalities in meiosis are often causes of infertility and birth defects (eg …

Tetrahymena thermophila is a ciliate–a unicellular eukaryote. Remarkably, every cell
maintains differentiated germline and somatic genomes: one silent, the other expressed …

Meiosis is a defining feature of eukaryotes but its phylogenetic distribution has not been
broadly determined, especially among eukaryotic microorganisms (ie protists)—which …

Background The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan
whose genome has been sequenced, enabling genome-wide analysis of gene expression …

Rediscovered as a potential eukaryotic epigenetic mark, DNA N6-adenine methylation
(6mA) varies across species in abundance and its relationships with transcription. Here we …

The presence of meiosis, which is a conserved component of sexual reproduction, across
organisms from all eukaryotic kingdoms, strongly argues that sex is a primordial feature of …

During the early meiotic prophase, connections are established between chromosomes and
cytoplasmic motors via a nuclear envelope bridge, known as a LINC (linker of …

Chromosome segregation in eukaryotes is driven by the kinetochore, a macromolecular
complex that connects centromeric DNA to microtubules of the spindle apparatus …

Replication of nuclear DNA occurs in the context of chromatin and is influenced by histone
modifications. In the ciliate Tetrahymena thermophila, we identified TXR1, encoding a …

Symbiodinium encompasses a diverse clade of dinoflagellates that are ecologically
important as symbionts of corals and other marine organisms. Despite decades of study …