Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

Mice communicate through audible vocalizations, which are within the human hearing
range, and ultrasonic vocalizations (USVs), which are above the upper limit of human …

Examination of rodent vocalizations in experimental conditions can yield valuable insights
into how disease manifests and progresses over time. It can also be used as an index of …

Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized
mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has …

The mechanistic understanding of lifestyle contributions to disease has been largely driven
by work in laboratory rodent models using environmental interventions. These interventions …

Huntington's disease (HD) is a neurodegenerative disease caused by a tandem repeat
mutation encoding an expanded polyglutamine tract. Our previous work showed that …

Olfactory dysfunction seems to occur earlier than classic motor and cognitive symptoms in
many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's …

Olfactory dysfunction and altered neurogenesis are observed in several neurodegenerative
disorders including Huntington disease (HD). These deficits occur early and correlate with a …

Olfactory dysfunction is observed in several neurological disorders, including Huntington
disease (HD), and correlates with global cognitive performance, depression and …

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder with
cognitive, psychiatric, motor, neuroendocrine and peripheral dysfunctions. Symptom onset …