Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface

MS Siegrist, BM Swarts, DM Fox, SA Lim… - FEMS microbiology …, 2015 - academic.oup.com
The cell surface is the essential interface between a bacterium and its surroundings.
Composed primarily of molecules that are not directly genetically encoded, this highly …

Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ

E Kuru, S Tekkam, E Hall, YV Brun… - Nature protocols, 2015 - nature.com
Fluorescent d-amino acids (FDAAs) are efficiently incorporated into the peptidoglycans
(PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and …

Imaging bacterial cell wall biosynthesis

AD Radkov, YP Hsu, G Booher… - Annual review of …, 2018 - annualreviews.org
Peptidoglycan is an essential component of the cell wall that protects bacteria from
environmental stress. A carefully coordinated biosynthesis of peptidoglycan during cell …

Covalent proteomimetic inhibitor of the bacterial FtsQB divisome complex

FM Paulussen, GK Schouten, C Moertl… - Journal of the …, 2022 - ACS Publications
The use of antibiotics is threatened by the emergence and spread of multidrug-resistant
strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In …

In Vivo Cross‐Linking Sheds Light on the Salmonella Divisome in Which PBP3 and PBP3SAL Compete for Occupancy

S Castanheira, D López‐Escarpa… - Molecular …, 2024 - Wiley Online Library
Bacterial cell division is orchestrated by proteins that assemble in dynamic complexes
collectively known as the divisome. Essential monofunctional enzymes with …

A green and convenient approach toward benzimidazole derivatives and their antimicrobial activity

J Wen, YL Luo, HZ Zhang, HH Zhao, CH Zhou… - Chinese Chemical …, 2016 - Elsevier
N-Alkylated benzimidazole derivatives have been synthesized via the aza-Michael addition
reactions of 1H-benzimidazoles to α, β-unsaturated compounds in water and palladium …

BT‐benzo‐29 inhibits bacterial cell proliferation by perturbing FtsZ assembly

S Ray, B Jindal, K Kunal, A Surolia… - The FEBS Journal, 2015 - Wiley Online Library
We have identified a potent antibacterial agent N‐(4‐sec‐butylphenyl)‐2‐(thiophen‐2‐yl)‐
1H‐benzo [d] imidazole‐4‐carboxamide (BT‐benzo‐29) from a library of benzimidazole …

Shape dynamics of growing cell walls

S Banerjee, NF Scherer, AR Dinner - Soft matter, 2016 - pubs.rsc.org
We introduce a general theoretical framework to study the shape dynamics of actively
growing and remodeling surfaces. Using this framework we develop a physical model for …

Copper-Catalyzed Inter/Intramolecular N-Alkenylation of Benzimidazoles via Tandem Processes Involving Selectively Mild Iodination of sp3 C–H Bond at α-Position …

TT Lai, D Xie, CH Zhou, GX Cai - The Journal of Organic …, 2016 - ACS Publications
Inter/intramolecular approaches to sp2 C–N bond formation of N-alkenyl benzimidazoles
have been accomplished in the presence of an iodide anion associated with a copper …

Making a chink in their armor: Current and next-generation antimicrobial strategies against the bacterial cell envelope

N Kadeřábková, AJS Mahmood, RCD Furniss… - Advances in microbial …, 2023 - Elsevier
Gram-negative bacteria are uniquely equipped to defeat antibiotics. Their outermost layer,
the cell envelope, is a natural permeability barrier that contains an array of resistance …