The regulation, functions and clinical relevance of arginine methylation

E Guccione, S Richard - Nature reviews Molecular cell biology, 2019 - nature.com
Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Protein arginine methyltransferases: promising targets for cancer therapy

JW Hwang, Y Cho, GU Bae, SN Kim… - Experimental & molecular …, 2021 - nature.com
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

[HTML][HTML] Arginine methylation: the coming of age

RS Blanc, S Richard - Molecular cell, 2017 - cell.com
Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

RNA G-quadruplexes in biology: principles and molecular mechanisms

MM Fay, SM Lyons, P Ivanov - Journal of molecular biology, 2017 - Elsevier
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

G-quadruplexes: prediction, characterization, and biological application

CK Kwok, CJ Merrick - Trends in biotechnology, 2017 - cell.com
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

G-quadruplexes and helicases

O Mendoza, A Bourdoncle, JB Boulé… - Nucleic acids …, 2016 - academic.oup.com
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

G-Quadruplexes in RNA biology: recent advances and future directions

L Dumas, P Herviou, E Dassi, A Cammas… - Trends in Biochemical …, 2021 - cell.com
RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression
mechanisms, from transcription to protein synthesis, and DNA-related processes. Their …

Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation

JY Fong, L Pignata, PA Goy, KC Kawabata, SCW Lee… - Cancer cell, 2019 - cell.com
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur
in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type …