The oral route is the most common route for drug administration. It is the most preferred
route, due to its advantages, such as non-invasiveness, patient compliance and …

Poor water-solubility remains a typical property of drug candidates in pharmaceutical
development pipelines today. Various processes have been developed to increase the …

Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug
compounds that limits in vivo bioavailability owing to their low dissolution rate in the …

Various drug delivery approaches can be used to maximize therapeutic efficacy and
minimize side effects, by impacting absorption, distribution, metabolism, and elimination …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Purpose Three-dimensional printing (3DP) is a rapidly growing additive manufacturing
process and it is predicted that the technology will transform the production of goods across …

Cyclodextrins are useful functional excipients that have enjoyed widespread attention and
use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these …

Solubility has a crucial role in the success of a drug candidate. Compounds with low
solubility not only cause problems for in vitro and in vivo assays, but also add significant …

Purpose The purpose of this paper is to discuss the pharmaceutical Quality by Design (QbD)
and describe how it can be used to ensure pharmaceutical quality. Materials and Methods …

Poorly water-soluble drug candidates often emerge from contemporary drug discovery
programs, and present formulators with considerable technical challenges. The absorption …