Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Lymphadenopathy in children for which no infectious or malignant cause can be ascertained
constitutes a challenging diagnostic dilemma. Autoimmune lymphoproliferative syndrome …

X-linked lymphoproliferative syndromes (XLP) are primary immunodeficiencies
characterized by a particular vulnerability toward Epstein-Barr virus infection, frequently …

The mammalian immune system has evolved over many millennia to be best equipped to
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

The Histiocytoses are defined as non-malignant disorders due to abnormal accumulation
and behavior of cells of the mononuclear phagocytic system. The best known histiocytoses …

Epstein–Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide
without serious sequela. However, for patients who have genetic diseases which predispose …

X-linked inhibitor of apoptosis (XIAP) deficiency, caused by BIRC4 mutations, is described to
cause X-linked lymphoproliferative disease (XLP) phenotypes. However, compared with …

Epstein-Barr virus (EBV) infects nearly all humans and usually is asymptomatic, or in the
case of adolescents and young adults, it can result in infectious mononucleosis. EBV …