Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives

D Becerra, R Abonia, JC Castillo - Molecules, 2022 - mdpi.com
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

[HTML][HTML] An overview on medicinal perspective of thiazolidine-2, 4-dione: A remarkable scaffold in the treatment of type 2 diabetes

G Bansal, PV Thanikachalam, RK Maurya… - Journal of advanced …, 2020 - Elsevier
Diabetes or diabetes mellitus is a complex or polygenic disorder, which is characterized by
increased levels of glucose (hyperglycemia) and deficiency in insulin secretion or resistance …

Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies

R Mehmood, EU Mughal, EB Elkaeed, RJ Obaid… - ACS …, 2022 - ACS Publications
In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …

Novel hybrids of benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment

R Bhutani, DP Pathak, G Kapoor, A Husain… - Bioorganic chemistry, 2019 - Elsevier
A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti …

KRA Abdellatif, WAA Fadaly, GM Kamel… - Bioorganic …, 2019 - Elsevier
Nowadays, diabetes and its associated inflammatory complications are important public
health problems worldwide. Market limitations of drugs with dual actions as anti …

Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1, 2, 3-triazole hybrids

L Kumar, K Lal, P Yadav, A Kumar, AK Paul - Journal of Molecular Structure, 2020 - Elsevier
A series of molecular hybrids based on pyrazoline and 1, 2, 3-triazole pharmacophores
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …

Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor

M Duhan, R Singh, M Devi, J Sindhu… - Journal of …, 2021 - Taylor & Francis
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …

[HTML][HTML] Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

A Drakontaeidi, I Papanotas, E Pontiki - Antioxidants, 2024 - mdpi.com
Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

U Farwa, MA Raza - RSC advances, 2022 - pubs.rsc.org
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …

Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

G Verma, G Chashoo, A Ali, MF Khan, W Akhtar, I Ali… - Bioorganic …, 2018 - Elsevier
Depravity of malaria in terms of morbidity and mortality in human beings makes it a major
health issue in tropical and subtropical areas of the globe. Drug counterfeiting and non …