Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …

Second-generation chimeric antigen receptors (CARs) retarget and reprogramme T cells to
augment their antitumour efficacy. The combined activating and co-stimulatory domains …

Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …

Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …

As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …