The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …

Recognition of pathogen‐associated molecular signatures is critically important in proper
activation of the immune system. The toll‐like receptor (TLR) signaling network is …

Members of the NF-κB/Rel and inhibitor of apoptosis (IAP) protein families have been
implicated in signal transduction programs that prevent cell death elicited by the cytokine …

The NF-κB transcription factor is a central mediator of inflammatory and innate immune
signaling pathways. Activation of NF-κB is achieved by K63-linked polyubiquitination of key …

The field of apoptosis is unusual in several respects. Firstly, its general importance has been
widely recognised only in the past few years and its surprising significance is still being …

Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions
including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly …

The zinc finger protein A20 is a tumor necrosis factor (TNF)–and interleukin 1 (IL-1)-
inducible protein that negatively regulates nuclear factor-kappa B (NF-κB)–dependent gene …

Clinicians have suspected for hundreds of years that chronic activation of the immune
system contributes to the development of cancer. However, the molecular mechanisms that …

Proper gene expression and cell growth are critical for the survival of all organisms. Nuclear
factor-kappaB (NF-κB)-dependent gene expression and apoptosis play crucial roles in …

A20 (also known as TNFAIP3) is a cytoplasmic protein that plays a key role in the negative
regulation of inflammation and immunity. Polymorphisms in the A20 gene locus have been …