A review of the role of flavonoids in peptic ulcer (2010–2020)

C Serafim, ME Araruna, EA Júnior, M Diniz… - Molecules, 2020 - mdpi.com
Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that
may reach the muscle layer. Their etiology is multifactorial and occurs when the balance …

Drug discovery strategies for modulating oxidative stress in gastrointestinal disorders

T Mousavi, N Hadizadeh, S Nikfar… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Due to the ever-growing incidence of gastrointestinal disorders accompanied by
substantial economic impact, it is of great importance to manage these conditions globally …

Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis

HM Selim, WA Negm, MF Hawwal, IA Hussein… - International …, 2023 - Elsevier
This study aimed to elucidate the gastro-protective effect of fucoidan against ethanol-
induced gastric ulcer mediated via NLRP3-induced pyroptosis as an underlying mechanism …

Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway

AAM Sallam, SF Darwish, WA El-Dakroury… - Pharmaceutical …, 2021 - Springer
Aims Gastric ulcer is a continuous worldwide threat that inquires protective agents.
Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having …

Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer

E Tamaddonfard, A Erfanparast, AA Farshid, M Imani… - Life sciences, 2019 - Elsevier
Aims Several natural products have been evaluated for management of gastric ulcer
induced by non-steroidal anti-inflammatory drugs. Safranal, a plant-derived chemical, has a …

Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses

A Jafari, N Andishfar, Z Esmaeilzadeh… - Basic & Clinical …, 2022 - Wiley Online Library
Topiramate is an anticonvulsant drug effective against a wide range of seizures and
epilepsies. The present study was conducted to investigate the possible protective effect of …

Interplay of biochemical, genetic, and immunohistochemical factors in the etio-pathogenesis of gastric ulcer in rats: a comparative study of the effect of pomegranate …

NM Abd El-Rady, MA Dahpy, A Ahmed… - Frontiers in …, 2021 - frontiersin.org
Background Few data are available about the role of herbal extract loaded nanoparticles as
an alternative safe medicine for the management of a gastric ulcer. Aim This work is targeted …

ALDH2 ameliorates ethanol-induced gastric ulcer through suppressing NLPR3 inflammasome activation and ferroptosis

Y Zhang, Z Yuan, J Chai, D Zhu, X Miao, J Zhou… - Archives of biochemistry …, 2023 - Elsevier
Gastric ulcer (GU) is a prevalent and life-threating gastrointestinal disorder. Aldehyde
dehydrogenase 2 (ALDH2) is a pivotal component of alcohol metabolism which has been …

The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway

EY AbdelAziz, MG Tadros, ET Menze - European Journal of Pharmacology, 2021 - Elsevier
Gastric ulcer is a very common disease that represent an economic burden. Non-steroidal
anti-inflammatory drugs induce ulcer in old patients and in patients with comorbidities …

New Insight on the Cytoprotective/Antioxidant Pathway Keap1/Nrf2/HO-1 Modulation by Ulva intestinalis Extract and Its Selenium Nanoparticles in Rats with …

M Almukainzi, TA El-Masry, H Selim, A Saleh… - Marine Drugs, 2023 - mdpi.com
Currently, there is growing interest in exploring natural bioactive compounds with anti-
inflammatory potential to overcome the side effects associated with the well-known synthetic …