Background Pharmacological interactions are useful for understanding ligand binding
mechanisms of a therapeutic target. These interactions are often inferred from a set of active …

A powerful early approach to evaluating the druggability of proteins involved determining the
hit rate in NMR-based screening of a library of small compounds. Here, we show that a …

Drug Discovery is an active research area that demands great investments and generates
low returns due to its inherent complexity and great costs. To identify potential therapeutic …

Adenosine kinase (AK) catalyzes the phosphorylation of adenosine (Ado) to AMP by means
of a kinetic mechanism in which the two substrates Ado and ATP bind the enzyme in a …

A quantitative analysis of the relationship between the structure and inhibitory activity
against the herpes simplex virus thymidine kinase (HSV-TK) was performed for the series of …

A convenient and efficient one-pot N-alkylation of nucleobases from alcohols using N-(p-
toluenesulfonyl) imidazole (TsIm) is described. In this method, treatment of alcohols with a …

Herpes B virus (B virus [BV]) is a macaque herpesvirus that is occasionally transmitted to
humans where it can cause rapidly ascending encephalitis that is often fatal. To understand …

Direct anti-tuberculosis screening of commercially available compound libraries identified a
novel piperidinol with interesting anti-tuberculosis activity and drug like characteristics. To …

A new strategy is reported for the C− H/C− H functionalization of 7‐azaindazoles at the C6‐
position through a regioselective oxidative arylation using N‐oxide activation. This …

Herpes simplex virus thymidine kinase type 1 (HSV1-TK) is frequently used as reporter
protein in gene therapy. Our aim is to produce single photon emitting reporter probe based …