Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

GDF15 promotes weight loss by enhancing energy expenditure in muscle

D Wang, LK Townsend, GJ DesOrmeaux, SM Frangos… - Nature, 2023 - nature.com
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men

RW Morton, SY Oikawa, CG Wavell… - Journal of applied …, 2016 - journals.physiology.org
We reported, using a unilateral resistance training (RT) model, that training with high or low
loads (mass per repetition) resulted in similar muscle hypertrophy and strength …

High sensitivity top–down proteomics captures single muscle cell heterogeneity in large proteoforms

JA Melby, KA Brown, ZR Gregorich… - Proceedings of the …, 2023 - National Acad Sciences
Single-cell proteomics has emerged as a powerful method to characterize cellular
phenotypic heterogeneity and the cell-specific functional networks underlying biological …

Muscle fibre activation is unaffected by load and repetition duration when resistance exercise is performed to task failure

RW Morton, MW Sonne, A Farias Zuniga… - The Journal of …, 2019 - Wiley Online Library
Key points Performing resistance exercise with heavier loads is often proposed to be
necessary for the recruitment of larger motor units and activation of type II muscle fibres …

Muscle stem cells contribute to myofibres in sedentary adult mice

AC Keefe, JA Lawson, SD Flygare, ZD Fox… - Nature …, 2015 - nature.com
Skeletal muscle is essential for mobility, stability and whole body metabolism, and muscle
loss, for instance, during sarcopenia, has profound consequences. Satellite cells (muscle …

Mitochondria transplant therapy improves regeneration and restoration of injured skeletal muscle

SE Alway, HG Paez, CR Pitzer… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Injection of exogenous mitochondria has been shown to improve the ischaemia‐
damaged myocardium, but the effect of mitochondrial transplant therapy (MTT) to restore …

The effects of obesity on skeletal muscle regeneration

D Akhmedov, R Berdeaux - Frontiers in physiology, 2013 - frontiersin.org
Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations

JL Saben, AL Boudoures, Z Asghar, A Thompson… - Cell reports, 2016 - cell.com
Maternal obesity impairs offspring health, but the responsible mechanisms are not fully
established. To address this question, we fed female mice a high-fat/high-sugar diet from …