Aminoacyl-tRNA synthetases (ARSs) are enzymes that catalyze the ligation of amino acids
to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired …

The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the
protein translation machinery. With the progressive increase in structure-based studies on …

Abstract Aminoacyl-tRNA synthetases (aaRSs), essential components of the protein
synthesizing machinery, have been often chosen for devising therapeutics against parasitic …

Introduction The apicomplexan parasite Cystoisospora suis has global significance as an
enteropathogen of suckling piglets. Its intricate life cycle entails a transition from an asexual …

Aminoacyl‐tRNA synthetases (AaRSs) are valuable “housekeeping” enzymes that ensure
the accurate transmission of genetic information in living cells, where they aminoacylated …

Malaria poses an enormous threat to human health. With ever increasing resistance to
currently deployed drugs, breakthrough compounds with novel mechanisms of action are …

Malaria drug research and development efforts have resurged in the last decade following
the decelerating rate of mortality and malaria cases in endemic regions. The inefficiency of …

Entamoeba histolytica (E. histolytica) exhibits a remarkable capacity to respond to thermal
shock stress through a sophisticated genetic regulation mechanism. This process is carried …

Visceral leishmaniasis is caused by Leishmania donovani which affects the poorer sections
of society, and despite the global spread, effective treatment is unavailable. The current …

Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of
apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth …