Bat-borne virus diversity, spillover and emergence
Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …
The phylogenomics of evolving virus virulence
JL Geoghegan, EC Holmes - Nature Reviews Genetics, 2018 - nature.com
How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …
emergence. Our current understanding of virulence evolution is based on insights drawn …
The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses
T Goldstein, SJ Anthony, A Gbakima, BH Bird… - Nature …, 2018 - nature.com
Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV)
detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and …
detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and …
Viruses are a dominant driver of protein adaptation in mammals
Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against
viruses has only been studied in a few proteins specialized in antiviral defense. Whether …
viruses has only been studied in a few proteins specialized in antiviral defense. Whether …
Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Bats host virulent zoonotic viruses without experiencing disease. A mechanistic
understanding of the impact of bats' virus hosting capacities, including uniquely constitutive …
understanding of the impact of bats' virus hosting capacities, including uniquely constitutive …
[HTML][HTML] Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic
The magnitude of the 2013–2016 Ebola virus disease (EVD) epidemic enabled an
unprecedented number of viral mutations to occur over successive human-to-human …
unprecedented number of viral mutations to occur over successive human-to-human …
[HTML][HTML] Human adaptation of Ebola virus during the West African outbreak
The 2013–2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It
began following the cross-species transmission of EBOV from an animal reservoir, most …
began following the cross-species transmission of EBOV from an animal reservoir, most …
Bats as viral reservoirs
DTS Hayman - Annual review of virology, 2016 - annualreviews.org
Bats are hosts of a range of viruses, including ebolaviruses, and many important human viral
infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I …
infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I …
[HTML][HTML] Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats
J Tian, J Sun, D Li, N Wang, L Wang, C Zhang, X Meng… - Cell Reports, 2022 - cell.com
Emerging infectious diseases, especially if caused by bat-borne viruses, significantly affect
public health and the global economy. There is an urgent need to understand the …
public health and the global economy. There is an urgent need to understand the …
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect
against Ebola virus and other filoviruses. The conserved, essential interaction between the …
against Ebola virus and other filoviruses. The conserved, essential interaction between the …