Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

How to make a neuron, a synapse, and a neural circuit? Is there only one 'design'for a
neural architecture with a universally shared genomic blueprint across species? The brief …

Pelagic larval stages are widespread across animals, yet it is unclear whether larvae were
present in the last common ancestor of animals or whether they evolved multiple times due …

Bryophytes represent a sister to the rest of land plants. Despite their evolutionary importance
and relatively simple body plan, a comprehensive understanding of the cell types and …

Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with
similar adaptive immune responses. However, the diversity of functional subtypes and …

Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate
cis-regulatory elements (cCREs) in non-mammal species has limited our exploration of …

INTRODUCTION Experimental models are essential tools in neurodegenerative disease
research. However, the translation of insights and drugs discovered in model systems has …