Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Caveolae, flask-like invaginations of the plasma membrane, were discovered nearly 60
years ago. Originally regarded as fixation artifacts of electron microscopy, the functional role …

Major clinical trials with sodium glucose co-transporter-2 inhibitors (SGLT-2i) exhibit
protective effects against heart failure events, whereas inconsistencies regarding the …

Background—Ischemic heart disease is the greatest cause of death in Western countries.
The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that mediate posttranscriptional
gene silencing. Mitochondrial fission participates in the induction of apoptosis. It remains …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Epigenetics represents a phenomenon of altered heritable phenotypic expression of genetic
information occurring without changes in DNA sequence. Epigenetic modifications control …

Significance: The term epigenetics refers to the changes in the phenotype and gene
expression that occur without alterations in the DNA sequence. There is a rapidly growing …

The purpose of this study was to investigate whether caveolin-3 (Cav3) regulates
localization of β 2-adrenergic receptor (β 2 AR) and its cAMP signaling in healthy or failing …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …