Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

In unicellular organisms, initiation is the rate-limiting step in transcription; in metazoan
organisms, the transition from initiation to productive elongation is also important. Here, we …

The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …

The Integrator complex processes 3′-ends of spliceosomal small nuclear RNAs (snRNAs).
Furthermore, it regulates transcription of protein coding genes by terminating transcription …

The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II)
comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6 …

Integrator (INT) is a transcriptional regulatory complex associated with RNA polymerase II
that is required for the 3′-end processing of both UsnRNAs and enhancer RNAs. Integrator …

Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated
with neurodevelopmental and neurodegenerative disorders characterized by …

The zebrafish (Danio rerio) is a model organism making useful contributions in many areas
of biological research. Zebrafish have proven particularly suitable for studying early …

Integrator is an RNA polymerase II (RNAPII)-associated complex that was recently identified
to have a broad role in both RNA processing and transcription regulation. Importantly, its …