Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of
structural proteins and glycosaminoglycans. The ECM provides essential physical …

Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …

The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …

Andrographolide is a major diterpenoid of Andrographis paniculata and possesses several
biological activities, including protection against oxidative stress mediated neurotoxicity …

Natural products are fascinating molecules in drug discovery for their exciting structure
variability and also for their interaction with various targets. Drugs multi-targeting effect …

Natural products are major molecules for drug discovery due to their structural diversity and
their interaction with various biological targets, yet their clinical application is limited by poor …

(1) Background: Andrographolide (AG) is a natural compound effective for the treatment of
inflammation-mediated neurodegenerative disorders. The aim of this investigation was the …

Background Progressive accumulation of α-synuclein is a key step in the pathological
development of Parkinson's disease. Impaired protein degradation and increased levels of α …

Purpose Baicalin (BA) has a good neuroprotective effect, but it is eliminated quickly in the
body and does not easily reach the brain. In this experiment, borneol (BO) was used as an …

Salvia miltiorrhiza Bunge (Lamiaceae), one of the most commonly used traditional Chinese
herbs, is widely used for the treatment of cardiovascular disease, cerebrovascular disease …