Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease
Abstract The International Mouse Phenotyping Consortium (IMPC; https://www.
mousephenotype. org/) web portal makes available curated, integrated and analysed …
mousephenotype. org/) web portal makes available curated, integrated and analysed …
[HTML][HTML] Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
High-throughput discovery of novel developmental phenotypes
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting
from knockouts of these genes in mice have provided tremendous insight into gene function …
from knockouts of these genes in mice have provided tremendous insight into gene function …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Placentation defects are highly prevalent in embryonic lethal mouse mutants
V Perez-Garcia, E Fineberg, R Wilson, A Murray… - Nature, 2018 - nature.com
Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse
gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused …
gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused …
Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
C Medina-Gomez, JP Kemp, K Trajanoska… - The American Journal of …, 2018 - cell.com
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
There is considerable controversy regarding epigenetic inheritance in mammalian gametes.
Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a …
Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a …
Emerging and evolving concepts in gene essentiality
Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …
fundamental and applied research. Multiple screens have been performed over the years in …