Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …

Amino acids are among the most important molecules in nature since they play central roles
both as building blocks of proteins and as intermediates in metabolism. The amino acid …

Staphylococcus aureus poses a severe public health problem as one of the vital causative
agents of healthcare-and community-acquired infections. There is a globally urgent need for …

Lysine riboswitches are bacterial RNA structures that sense the concentration of lysine and
regulate the expression of lysine biosynthesis and transport genes. Members of this …

Comparative analysis of genes, operons and regulatory elements was applied to the lysine
biosynthetic pathway in available bacterial genomes. We report identification of a lysine …

Riboswitches are structured non-coding RNAs found in the 5′ UTR of important genes for
bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can …

The synthesis of meso-diaminopimelic acid (m-DAP) in bacteria is essential for both
peptidoglycan and lysine biosynthesis. From genome sequencing data, it was unclear how …

The endosymbiotic Wolbachia is one of the most common intracellular bacteria known in
arthropods and nematodes. Its ability for reproductive manipulation can cause unequal …

Dihydrodipicolinate synthase (DHDPS, EC 4.2. 1.52) catalyses the branchpoint reaction of
lysine biosynthesis in plants and microbes: the condensation of (S)-aspartate-β …

Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …