From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is
implicated in cancer and DNA damage response (DDR) pathways are in place against this …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

ATR checkpoint signaling is crucial for cellular responses to DNA replication impediments.
Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self …

The efficiency of homologous recombination (HR) in the repair of DNA double-strand breaks
(DSBs) is closely associated with genome stability and tumor response to chemotherapy …

The regulation of DNA double-strand breaks (DSBs) and telomeres are diametrically
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …

The ATR kinase is crucial for genome maintenance, but the mechanisms by which ATR
controls the DNA repair machinery are not fully understood. Here, we find that long-term …

Abstract TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA
replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation …

Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the
small DNA tumour viruses. Notably, human adenoviruses were the first human viruses …

Prostate cancer (PCa) is a disease of mutated and misregulated genes. However, primary
prostate tumors have relatively few mutations, and only three genes (ERG, PTEN, and …