Clinical management and innovation in fracture non-union

C Siverino, WJ Metsemakers, R Sutter… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction With the introduction and continuous improvement in operative fracture fixation,
even the most severe bone fractures can be treated with a high rate of successful healing …

Advances in Dynamization of Plate Fixation to Promote Natural Bone Healing

M Bottlang, SS Shetty, C Blankenau, J Wilk… - Journal of Clinical …, 2024 - mdpi.com
The controlled dynamization of fractures can promote natural fracture healing by callus
formation, while overly rigid fixation can suppress healing. The advent of locked plating …

Strengthening mechanism of TPMS interpenetrating phase composites for bone tissue engineering

H Xie, Y Wang, F Liu, Q Tang, J Chen, T Luo, X Bian - Composite …, 2024 - Elsevier
Multicomponent functional scaffolds hold great promise as implanted materials with
compatible mechanical properties and biological functionalities. Interpenetrating phase …

Finite element simulations of smart fracture plates capable of cyclic shortening and lengthening: which stroke for which fracture?

M Roland, S Diebels, K Wickert… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction: Bone healing can be improved by axial micromovement, as has been shown in
animals and human patients with external fixators. In the development of smart fracture …

Prognostic bone fracture healing simulations in an ovine tibia model validated with in vivo sensors

P Schwarzenberg, J Schlatter, M Ernst… - Journal of …, 2025 - Wiley Online Library
Bone fracture healing is a complex physiological process influenced by biomechanical and
biomolecular factors. Mechanical stability is crucial for successful healing, and disruptions …

Refinement in Post-Operative Care for Orthopaedic Models: Implementing a Sheep Walking Cast (SWC) for Effective Tibial Fracture Management

IJ Knorr, L Tix, W Liu, SR Talbot, M Schulz, L Bell… - Biomedicines, 2024 - mdpi.com
In the healthcare system, lower leg fractures remain relevant, incurring costs related to
surgical treatment, hospitalization, and rehabilitation. The duration of treatment may vary …

Don't mind the gap: reframing the Perren strain rule for fracture healing using insights from virtual mechanical testing

M Tanveer, K Klein, B von Rechenberg… - Bone & Joint …, 2025 - boneandjoint.org.uk
Aims The “2 to 10% strain rule” for fracture healing has been widely interpreted to mean that
interfragmentary strain greater than 10% predisposes a fracture to nonunion. This …

Discretizing low‐intensity whole‐body vibration into bouts with short rest intervals promotes bone defect repair in osteoporotic mice

T Matsumoto, K Hashimoto… - Journal of Orthopaedic …, 2024 - Wiley Online Library
Continuous administration of low‐intensity whole‐body vibration (WBV) gradually
diminishes bone mechanosensitivity over time, leading to a weakening of its osteogenic …

Multicomponent Functional Scaffolds with Multiscale Porosity to Improve Biomimetic and Mechanical Properties

F Liu, J Chen, Y Wang, T Luo, X Zhang, X Wang… - Available at SSRN … - papers.ssrn.com
Multicomponent functional scaffolds hold great promise as implanted materials with
compatible mechanical properties and biological functionalities. Interpenetrating phase …

A Murine Delayed-Healing Model Associates Immune Response with Functional Bone Regeneration after Trauma

M Patrick, A Stromberg, J Ahn, K Hankenson… - bioRxiv, 2023 - biorxiv.org
Nonunion and delayed-union fractures pose a significant clinical challenge, often leading to
prolonged morbidity and impaired quality of life. Fracture-induced hematoma and acute …