Methamphetamine (meth) addiction is a prevalent health concern worldwide, yet remains
without approved pharmacological treatments. Preclinical evidence suggests that oxytocin …

Many overweight or obese people struggle to sustain the behavioural changes necessary to
achieve and maintain weight loss. In rodents, obesogenic diet can disrupt goal-directed …

High‐palatable and caloric foods are widely overconsumed due to hedonic mechanisms
that prevail over caloric necessities leading to overeating and overweight. The nucleus …

The incubation of cue-reinforced cocaine-seeking coincides with increased extracellular
glutamate within the ventromedial prefrontal cortex (vmPFC). The vmPFC is comprised of …

Abstract Phosphatidylinositide 3‐kinases (PI3Ks) are intracellular signal transducer
enzymes that recruit protein kinase B (aka Akt) to the cell membrane, the subsequent …

The group 2 metabotropic glutamate receptor (mGluR2/3) agonist, pomaglumetad methionil
(POM), showed promise as a novel antipsychotic in preclinical research but failed to show …

Rationale Adolescence is a period of considerable development of brain and behavior and
is the time during which most drug use is initiated. Objective Age-dependent differences in …

Objectives The mGlu2/3 receptor agonist LY379268 reduces sucrose-seeking, but not
sucrose-taking, in male rats. This study explored the generality of this effect across the …

Substance users who are female and begin their use during adolescence often suffer
greater consequences than male and adult-onset users. Methamphetamine (METH) use …

RATIONALE: Adolescence is a period of considerable development of brain and behavior
and is the time during which most drug use is initiated. OBJECTIVE: Age-dependent …