Influence of the tumor microenvironment on NK cell function in solid tumors
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …
host immune responses against infection and tumor growth. These cells have a powerful …
[HTML][HTML] Brain malignancies: Glioblastoma and brain metastases
Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells
Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
[HTML][HTML] EZH2, a prominent orchestrator of genetic and epigenetic regulation of solid tumor microenvironment and immunotherapy
S Sun, F Yu, D Xu, H Zheng, M Li - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy.
The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated …
The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated …
Natural killer cell therapy targeting cancer stem cells: old wine in a new bottle
F Guo, Y Zhang, L Bai, J Cui - Cancer Letters, 2023 - Elsevier
A small proportion of cancer cells that have stem cell-like properties are known as cancer
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis
Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …
Current progress of chimeric antigen receptor (CAR) T versus CAR NK cell for immunotherapy of solid tumors
Equipping cancer-fighting immune cells with chimeric antigen receptor (CAR) has gained
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …
Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …
[HTML][HTML] EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1
Background Natural killer (NK) cells can recognize and kill cancer cells directly, but their
activity can be attenuated by various inhibitory molecules expressed on the surface. The …
activity can be attenuated by various inhibitory molecules expressed on the surface. The …
Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the …
Introduction and methods In this study we report that sequential treatment of supercharged
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …