▪ Abstract Neuroregulators found at various brain sites are involved in controlling food
intake, a behavior that occurs for many reasons. Different neuroregulators may affect …

While much has been elucidated about the hypothalamic controls of energy balance, the
epidemic of obesity continues to escalate. Recent work has suggested that extra …

The evidence that NPY is an endogenous neurotransmitter that modulates both sides of the
energy equation is clear and compelling. While agreeing with this (and indeed contributing …

Peptide YY (PYY) is the most potent orexigenic peptide or substance known. However,
neither the underlying physiology of this hyperphagia nor PYY's natural role in brain are well …

The way people come to report private stimulation (eg, feeling states) arising within their
own bodies is not well understood. Although the Darwinian assumption of biological …

Clark and colleagues first described the robust orexigenic effects of neuropeptide Y (NPY) in
1984. Our group as well as Stanley et al. confirmed these effects in the same year. During …

AIM: The aim of this review is to critically assess available evidence that blockade of the
actions of NPY at one of the five NPY receptor subtypes represents an attractive new drug …

Neuropeptide Y has been extensively studied in the central nervous system due to a
possible involvement of neuropeptide Y-containing neurons in cognitive functions. In the …

Centrally injected neuropeptide Y (NPY) is a potent stimulant of ingestive behavior capable
of augmenting both food and fluid intake in fully satiated animals. To gain further insight into …

Central injection of peptide YY (PYY) in sated rats produces the most powerful stimulating
effect of food intake known to date. The neural mechanisms by which PYY regulates appetite …