Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Estrogen: a master regulator of bioenergetic systems in the brain and body

JR Rettberg, J Yao, RD Brinton - Frontiers in neuroendocrinology, 2014 - Elsevier
Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

Sexual dimorphism in predisposition to Alzheimer's disease

DW Fisher, DA Bennett, H Dong - Neurobiology of aging, 2018 - Elsevier
Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

Postmenopausal hormone therapy: an Endocrine Society scientific statement

RJ Santen, DC Allred, SP Ardoin… - The Journal of …, 2010 - academic.oup.com
Objective: Our objective was to provide a scholarly review of the published literature on
menopausal hormonal therapy (MHT), make scientifically valid assessments of the available …

Is hormone replacement therapy a risk factor or a therapeutic option for Alzheimer's disease?

ZB Mills, RLM Faull, A Kwakowsky - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …

Screening for dementia in primary care: a summary of the evidence for the US Preventive Services Task Force

M Boustani, B Peterson, L Hanson… - Annals of internal …, 2003 - acpjournals.org
Background: Dementia is a large and growing problem but is often not diagnosed in its
earlier stages. Screening and earlier treatment could reduce the burden of suffering of this …

Sex hormones and cognition: neuroendocrine influences on memory and learning.

DK Hamson, MM Roes, LAM Galea - 2016 - open.library.ubc.ca
Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Treatment of multiple sclerosis with the pregnancy hormone estriol

NL Sicotte, SM Liva, R Klutch, P Pfeiffer… - Annals of Neurology …, 2002 - Wiley Online Library
Multiple sclerosis patients who become pregnant experience a significant decrease in
relapses that may be mediated by a shift in immune responses from T helper 1 to T helper 2 …

Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen

SA Castellon, PA Ganz, JE Bower… - Journal of clinical and …, 2004 - Taylor & Francis
The primary aim of the current study was to examine whether neurocognitive functioning
among breast cancer survivors (BCS) exposed to systemic adjuvant chemotherapy differs …

The glutamatergic system and Alzheimer's disease: therapeutic implications

DA Butterfield, CB Pocernich - CNS drugs, 2003 - Springer
Alzheimer's disease affects nearly 5 million Americans currently and, as a result of the baby
boomer cohort, is predicted to affect 14 million Americans and 22 million persons totally …