Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the
metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating …

Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether
and how the mechanical properties of the local tissue influence their response to treatment …

Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

Over the past decades, increasing evidence has indicated that mechanical loads can
regulate the morphogenesis, proliferation, migration, and apoptosis of living cells …

Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis.
Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular …

Cancer research has considerably progressed with the improvement of in vitro study
models, helping to understand the key role of the tumor microenvironment in cancer …

Delayed relapses at distant sites are a common clinical observation for certain types of
cancers after removal of primary tumor, such as breast and prostate cancer. This evidence …