The pathogenesis of the antiphospholipid syndrome
B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …
[HTML][HTML] The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS
T McDonnell, C Wincup, I Buchholz, C Pericleous… - Blood reviews, 2020 - Elsevier
Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …
Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …
one of the most common causes of dementia worldwide, accounting for about 80% of all …
[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function
PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …
Thiol switches in membrane proteins-Extracellular redox regulation in cell biology
I Lorenzen, JA Eble, EM Hanschmann - Biological chemistry, 2021 - degruyter.com
Redox-mediated signal transduction depends on the enzymatic production of second
messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as …
messengers such as hydrogen peroxide, nitric oxide and hydrogen sulfite, as well as …
Post-translational control of protein function by disulfide bond cleavage
Protein action in nature is largely controlled by the level of expression and by post-
translational modifications. Post-translational modifications result in a proteome that is at …
translational modifications. Post-translational modifications result in a proteome that is at …
β2-Glycoprotein I: a novel component of innate immunity
Ç Ağar, PG de Groot, M Mörgelin… - Blood, The Journal …, 2011 - ashpublications.org
Sepsis is a systemic host response to invasive infection by bacteria. Despite treatment with
antibiotics, current mortality rates are in the range of 20%-25%, which makes sepsis the …
antibiotics, current mortality rates are in the range of 20%-25%, which makes sepsis the …
Thiol–Disulfide exchange reactions in the mammalian extracellular environment
Disulfide bonds represent versatile posttranslational modifications whose roles encompass
the structure, catalysis, and regulation of protein function. Due to the oxidizing nature of the …
the structure, catalysis, and regulation of protein function. Due to the oxidizing nature of the …
Changing perspectives from oxidative stress to redox signaling—extracellular redox control in translational medicine
Extensive research has changed the understanding of oxidative stress that has been linked
to every major disease. Today we distinguish oxidative eu-and distress, acknowledging that …
to every major disease. Today we distinguish oxidative eu-and distress, acknowledging that …
Naturally occurring free thiols within β2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress–induced cell …
Abstract β2-Glycoprotein I (β2GPI) is an evolutionary conserved, abundant circulating
protein. Although its function remains uncertain, accumulated evidence points toward …
protein. Although its function remains uncertain, accumulated evidence points toward …