1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent
release of fatty acids are the initiating steps of inflammation. It is proposed in this study that …

Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …

The therapy of snakebite envenomation has been based on the parenteral administration of
animal-derived antivenoms. Despite the success of this treatment at reducing the impact of …

An increase in left ventricular collagen (cardiac fibrosis) is a detrimental process that
adversely affects heart function. Strong evidence implicates the infiltration of inflammatory …

Background Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide
range of biological and medicinal properties including anti-inflammatory activity. Therefore …

The human secretory phospholipase A2 group IIA (PLA2-IIA) is a lipolytic enzyme. Its
inhibition leads to a decrease in eicosanoids levels and, thereby, to reduced inflammation …

Accurately predicting relative binding affinities and biological potencies for ligands that
interact with proteins remains a significant challenge for computational chemists. Most …