Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Streptozotocin (STZ)-induced diabetes mellitus (DM) offers a very cost-effective and
expeditious technique that can be used in most strains of rodents, opening the field of DM …

The shortage of organs and cells from deceased individuals continues to restrict
allotransplantation. Pigs could provide an alternative source of tissue and cells but the …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Transplantation of pancreatic islets is a therapeutic option to preserve or restore β-cell
function. Our study was aimed at developing a clinically applicable protocol for extrahepatic …

Insulin-producing stem cell-derived islets (SC-islets) provide a virtually unlimited cell source
for diabetes cell replacement therapy. While SC-islets are less functional when first …

The liver is the current site of choice for pancreatic islet transplantation, even though it is far
from being an ideal site because of immunologic, anatomic, and physiologic factors leading …

Clinical islet transplantation has demonstrated success in treating type 1 diabetes. A current
limitation is the intrahepatic portal vein transplant site, which is prone to mechanical stress …

A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …

The portal vein is currently the site of choice for clinical islet transplantation, even though it is
far from being an ideal site. Low oxygen tension and the induction of an inflammatory …