In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

NMR has the resolution and specificity to determine atomic-level protein structures of
isotopically labeled proteins in complex environments, and with the sensitivity gains …

In-cell NMR spectroscopy is a powerful approach to study protein structure and function in
the native cellular environment. It provides precious insights into the folding, maturation …

Proteins often undergo large-scale conformational transitions, in which secondary and
tertiary structure elements (loops, helices, and domains) change their structures or their …

The cellular environment can affect the structure and function of pharmacological targets
and the interaction with potential drugs. Such complexity is often overlooked in the first steps …

Online analysis and monitoring of solution phase chemistry by way of nuclear magnetic
resonance spectroscopy on a recirculating sample from an external reaction vessel …

Depicting how biomolecules move and interact within their physiological environment is one
of the hottest topics of structural biology. This Feature Article gives an overview of the most …