Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

Surg Oncol Clin N Am 29 (2020) 127–144 http://dx. doi. org/10.1016/j. soc. 2019.08. 010
surgonc. theclinics. com 1055-3207/20/© 2019 Elsevier Inc. All rights reserved. diagnosed …

Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and
mortality rate around the world and seriously threatens public health. As an inevitable by …

Prostate cancer (PC) is the most commonly diagnosed cancer in men and is the second
leading cause of male cancer-related death in North America. Metabolic adaptations in …

Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the
regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed …

Matrix stiffening is ubiquitous in solid tumors and can direct epithelial–mesenchymal
transition (EMT) and cancer cell migration. Stiffened niche can even cause poorly invasive …

Osteoarthritis (OA) has traditionally been defined as a non-inflammatory disease. Recently,
many studies have demonstrated that OA also has an inflammatory component. BRD4, a …

Cancer is a multifactorial disease resulting from both genetic factors and epigenetic
changes. Histone acetylation, a post-translational modification, which alters chromatin …