Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

The vaginal microbiome is an intricate and dynamic microecosystem that constantly
undergoes fluctuations during the female menstrual cycle and the woman's entire life. A …

Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …

Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has led to unprecedented
responses in patients with high-risk hematologic malignancies. However, up to 60% of …

Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a
pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched …

Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a
genetic and multifactorial disease, influenced by the host and environmental factors. It has …

Infection is the second leading cause of death in patients with cancer. Loss of efficacy in
antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Importance The effect of rationally defined nonpathogenic, nontoxigenic, commensal strains
of Clostridia on prevention ofClostridioides difficileinfection (CDI) is unknown. Objective To …

The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …