The members of the genus Alphavirus are positive-sense RNA viruses, which are
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …

Viruses are intracellular parasites that use the host cell they infect to produce new infectious
progeny. Distinct steps of the virus life cycle occur in association with the cytoskeleton or …

Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and
alphaviruses, carry out transcription and replication inside virus-induced membranous …

Positive-strand RNA virus genome replication is invariably associated with extensively
rearranged intracellular membranes. Recent biochemical and electron microscopy …

Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell
membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like …

To better understand how positive-strand (+) RNA viruses assemble membrane-associated
replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics
resulting in predominantly symptomatic infections, which in rare cases cause long term …

Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in
humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and …

Alphaviruses are plus-strand RNA viruses that cause encephalitis, rash, and arthritis. The
nonstructural protein (nsP) precursor polyprotein is translated from genomic RNA and …

Alphaviruses are typically arthropod-borne, and many are important pathogens such as
chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1–4), initially …