This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …

Ferroptosis is a non-traditional form of regulated cell death, characterized by iron overload
and lipid peroxidation. Exploration of ferroptosis in chronic kidney disease (CKD) has been …

Abstract Background Sorafenib (Sor) is the only approved multikinase inhibitor indicated for
the treatment of HCC. Previous studies have shown that amygdalin (Amy) possesses …

Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and
the leading cause of end-stage renal disease. Although several pharmacological agents …

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most
significant microvascular complication of diabetes and poses a severe public health concern …

Cytochrome c (Cyt c) has both life-sustaining and cellular death-related functions,
depending on subcellular localization. Within mitochondria, Cyt c acts as a single electron …

BACKGROUND Cardiorenal syndrome (CRS)—renal injury during heart failure (HF)—is
linked to high morbidity. Whether circulating extracellular vesicles (EVs) and their RNA …

The intracellular energy state will alter under the influence of physiological or pathological
stimuli. In response to this change, cells usually mobilize various molecules and their …

Clinical studies suggest that non-alcoholic steatohepatitis (NASH) is an independent risk
factor for chronic kidney disease (CKD), but causality and mechanisms linking these two …