Cellular function is based on protein–protein interactions. A large proportion of these
interactions involves the binding of short linear motifs (SLiMs) by folded globular domains …

Motility of bacterial cells promotes a range of important physiological phenomena such as
nutrient detection, harm avoidance, biofilm formation, and pathogenesis. While much …

Phosphorylation and dephosphorylation of proteins by kinases and phosphatases are
central to cellular responses and function. The structural effects of serine and threonine …

Aberrant kinase activity contributes to the pathogenesis of brain cancers,
neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors that …

Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the
mechanisms regulating this dynamic process remain obscure. Here, we describe a …

Forkhead-associated (FHA) domain proteins specifically recognize phosphorylated
threonine via the FHA domain and are involved in signal transduction in various processes …

DNA replication fork stalling poses a major threat to genome stability. This is counteracted in
part by the intra‐S phase checkpoint, which stabilizes arrested replication machinery …

The ability of microorganisms to sense and respond to sudden changes in their environment
is often based on regulatory systems comprising reversible protein phosphorylation. The …

Survivin is an inhibitor of apoptosis family protein implicated in apoptosis and mitosis. In
apoptosis, it has been shown to recognize the Smac/DIABLO protein. It is also a component …

Several binding scaffolds that are not based on immunoglobulins have been designed as
alternatives to traditional monoclonal antibodies. Many of them have been developed to …