The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …
functions of the different cell types in the exocrine pancreas as well as the roles of these …
Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion
Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces
IS Ambudkar, LB de Souza, HL Ong - Cell calcium, 2017 - Elsevier
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
Orai1-mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity
The gut microbiome participates in numerous physiologic functions and communicates
intimately with the host immune system. Antimicrobial peptides are critical components of …
intimately with the host immune system. Antimicrobial peptides are critical components of …
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
Stromal interaction molecule (STIM1) and ORAI1 are key components of the Ca2+ release‐
activated Ca2+ (CRAC) current having an important role in T‐cell activation and mast cell …
activated Ca2+ (CRAC) current having an important role in T‐cell activation and mast cell …
Contribution and regulation of TRPC channels in store-operated Ca2+ entry
KT Cheng, HL Ong, X Liu, IS Ambudkar - Current topics in membranes, 2013 - Elsevier
Store-operated calcium entry (SOCE) is activated in response to depletion of the
endoplasmic reticulum-Ca 2+ stores following stimulation of plasma membrane receptors …
endoplasmic reticulum-Ca 2+ stores following stimulation of plasma membrane receptors …
The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis
RT Waldron, Y Chen, H Pham, A Go… - The Journal of …, 2019 - Wiley Online Library
Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …
Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives
Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …
responsible for the regulation of a variety of physiological functions. In the secretory …
Role of TRPC channels in store-operated calcium entry
HL Ong, LB de Souza, IS Ambudkar - … entry pathways in non-excitable cells, 2016 - Springer
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …