New insights into the activities and toxicities of the old anticancer drug doxorubicin
SY van der Zanden, X Qiao, J Neefjes - The FEBS journal, 2021 - Wiley Online Library
The anthracycline drug doxorubicin is among the most used—and useful—
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …
Transgenic mouse models in cancer research
The use of existing mouse models in cancer research is of utmost importance as they aim to
explore the casual link between candidate cancer genes and carcinogenesis as well as to …
explore the casual link between candidate cancer genes and carcinogenesis as well as to …
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued
opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic …
opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic …
Non-genetic determinants of malignant clonal fitness at single-cell resolution
All cancers emerge after a period of clonal selection and subsequent clonal expansion.
Although the evolutionary principles imparted by genetic intratumour heterogeneity are …
Although the evolutionary principles imparted by genetic intratumour heterogeneity are …
Targeting metastasis-initiating cells through the fatty acid receptor CD36
G Pascual, A Avgustinova, S Mejetta, M Martín… - Nature, 2017 - nature.com
The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …
unknown hampers the development of antimetastatic therapies. Here we describe a …
PPM1D mutations drive clonal hematopoiesis in response to cytotoxic chemotherapy
Clonal hematopoiesis (CH), in which stem cell clones dominate blood production, becomes
increasingly common with age and can presage malignancy development. The conditions …
increasingly common with age and can presage malignancy development. The conditions …
Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations
Chromosomal translocations encode oncogenic fusion proteins that have been proven to be
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …
Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy
D Forte, M García-Fernández, A Sanchez-Aguilera… - Cell metabolism, 2020 - cell.com
Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …
(BM) microenvironment for survival, but the underlying mechanisms remain largely …
Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche
Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one
shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing …
shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing …