Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients

E Duijvelaar, J Gisby, JE Peters, HJ Bogaard… - Nature …, 2024 - nature.com
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …

Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway

SN Roach, FK Shepherd, CK Mickelson… - Proceedings of the …, 2024 - pnas.org
Influenza viruses pose a significant burden on global human health. Influenza has a broad
cellular tropism in the airway, but how infection of different epithelial cell types impacts …

Canonical fibroblast growth factors in viral infection

G Lottini, E Plicanti, M Lai, P Quaranta… - Reviews in Medical …, 2023 - Wiley Online Library
Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in the
development and maintenance of various tissues in the body. There are three function‐al …

[HTML][HTML] The fundamentals of fibroblast growth factor 9

H Yin, SCR Staples, JG Pickering - Differentiation, 2024 - Elsevier
Abstract Fibroblast growth factor 9 (FGF9) was first identified during a screen for factors
acting on cells of the central nervous system (CNS). Research over the subsequent two …

FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases

D Stefanova, D Olszewski, M Glitscher, M Bauer… - Cellular and Molecular …, 2024 - Springer
The development of antiviral strategies is a key task of biomedical research, but broad-
spectrum virus inhibitors are scarce. Here we show that fibroblast growth factor receptor …

Longitudinal plasma proteomics reveals alveolar-capillary barrier disruption in critically ill COVID-19 patients

E Duijvelaar, J Gisby, J Peters, HJ Bogaard, J Aman - 2023 - researchsquare.com
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
direct viral cytopathic effects and a dysregulated host immune response. In a randomised …

Identification of candidate biomarkers and signaling pathways associated with Alzheimer's disease using bioinformatics analysis of next generation sequencing data

BM Vastrad, CM Vastrad - bioRxiv, 2024 - biorxiv.org
Alzheimer's disease (AD) is the most common cause of dementia, and one of the most
common health problems all over the world. However, the specific molecular mechanisms of …

Bioinformatics and next generation data analysis reveals the potential role of inflammation in sepsis and its associated complications

B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Sepsis is the leading systemic inflammatory response syndrome in worldwide, yet relatively
little is known about the genes and signaling pathways involved in sepsis progression. The …

[PDF][PDF] Microbial translocation disorders: a new concept in pathophysiology

A Sfera, S Hazan, MDA ProgenaBiome, Z Kozlakidis - brain - researchgate.net
The Human Microbiome Project, launched in in 2007, and the discovery of innate lymphoid
cells (ILCs) in 2008 are major advances that have begun to shed light on the pathogenesis …

[PDF][PDF] The Trespassing Bugs: Microbial Translocation Disorders

A Sfera, S Hazan, Z Kozlakidis - researchgate.net
The Human Microbiome Project, launched in in 2007, and the discovery of innate lymphoid
cells (ILCs) in 2008 are major advances that have begun to shed light on the pathogenesis …