Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Computational approaches are very necessary and useful resources in the process of drug
development. The goal of drug development is to identify a chemical compound that can fit …

Current treatment of clostridial infections includes broad-spectrum antibiotics and antitoxins,
yet antitoxins are ineffective against all Clostridium species. Moreover, rising antimicrobial …

The alarming increase in multi-and extensively drug-resistant (MDR and XDR) strains of
Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for …

In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives
(4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have …

Tuberculosis (TB) is a major global health challenge, with approximately 1.4 million deaths
per year. There is still a need to develop novel treatments for patients infected with …

Mycobacterium tuberculosis is the causative pathogen of the pulmonary disease
tuberculosis. Despite the availability of effective treatment programs, there is a global pursuit …

This review provides an overview of the most important novel treatment strategies against
Streptococcus pneumoniae infections published over the past 10 years. The pneumococcus …

Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug
resistant M. tuberculosis strains, which lead to the need of new more efficient drugs. A …