Cardiac sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) plays a central role in
myocardial contractility. SERCA2a actively transports Ca2+ into the SR and regulates …

The control of intracellular calcium is central to regulation of cardiac contractility. A defect in
SR Ca2+ transport and SR Ca2+ ATPase pump activity and expression level has been …

Background—Although downregulation of L-type Ca2+ current (I Ca, L) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …

This review deals with the influence of serine/threonine-specific protein phosphatases on
the function of ion channels in the plasma membrane of excitable tissues. Particular focus is …

Mobilization of endoplasmic reticulum Ca2+ is pivotal to the ability of a cell to send or
respond to stimuli. Ca2+–Mg2+-ATPases, termed SERCA pumps, sequester Ca2+ into the …

BACKGROUND: Pediatric myocardium is unique from mature myocardium; thus, the use of
adult cardioplegia for pediatric cardiac operations may provide suboptimal myocardial …

Diastolic dysfunction is characterized by prolonged relaxation, increased filling pressure,
decreased contraction velocity, and reduced cardiac output. Phenotypical features of …

We studied transgenic mice with cardiac-specific overexpression of H 2-histamine receptors
(H 2-TG) by using the α-myosin heavy-chain promoter. We wanted to address whether this …

We tested the hypothesis that altered phosphorylation of Ca 2+ regulatory proteins
contributes to contractile anomalies in cardiac hypertrophy. Cardiac hypertrophy was …

Cardioplegia has become the gold standard of myocardial protection for practically every
type of heart surgery during which the ascending aorta must be clamped. Although there is …