Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …

Gene transcription in animals involves the assembly of RNA polymerase II at core promoters
and its cell-type-specific activation by enhancers that can be located more distally. However …

Recombination is a fundamental biological process with profound evolutionary implications.
Theory predicts that recombination increases the effectiveness of selection in natural …

The RNA polymerase II core promoter is a structurally and functionally diverse
transcriptional regulatory element. There are two main strategies for transcription initiation …

The identification of transcriptional enhancers in the human genome is a prime goal in
biology. Enhancers are typically predicted via chromatin marks, yet their function is primarily …

The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …

The RNA polymerase II core promoter is generally defined to be the sequence that directs
the initiation of transcription. This simple definition belies a diverse and complex …

The RNA polymerase II core promoter is sometimes referred to as the gateway to
transcription. The core promoter is generally defined to be the stretch of DNA that directs the …

Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II)
accumulates to high densities on many promoters at a rate-limited step in transcription …