Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson's disease (PD)
and major efforts are underway to develop new therapeutics that target LRRK2 or …

Background Identifying hereditary parkinsonism is valuable for diagnosis, genetic
counseling, patient prioritization in trials, and studying the disease for personalized …

The prevalence of Parkinson's disease (PD) is increasing but the development of novel
treatment strategies and therapeutics altering the course of the disease would benefit from …

Background Parkinson's disease (PD) is a neurodegenerative movement disorder affecting
1–5% of the general population for which neither effective cure nor early diagnostic tools are …

Previous genetic studies on hereditary Parkinson's disease (PD) have identified a set of
pathogenic gene mutations that have strong impacts on the pathogenicity of PD. In addition …

Mutations in LRRK2 gene cause inherited Parkinson's disease (PD) and variations around
LRRK2 act as risk factor for disease. Similar to sporadic disease, LRRK2-linked cases show …

Background Most sequencing studies in Parkinson's disease (PD) have focused on either a
particular gene, primarily in familial and early onset PD samples, or on screening single …

Background: Increasing numbers of mutations causing monogenic forms of Parkinson's
disease (PD) have been described, mostly among patients in Europe and North America …

Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by
remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD …

Introduction Parkinson's disease (PD) has a complex genetic background involving both
rare and common genetic variants. Although a small percentage of cases show a clear …