Pathophysiology of migraine: a disorder of sensory processing

PJ Goadsby, PR Holland… - Physiological …, 2017 - journals.physiology.org
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Human models of migraine—short-term pain for long-term gain

M Ashina, JM Hansen, BO á Dunga… - Nature Reviews …, 2017 - nature.com
Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

JM Hansen, AW Hauge, J Olesen, M Ashina - Cephalalgia, 2010 - journals.sagepub.com
Introduction: Calcitonin gene-related peptide (CGRP) is a key molecule in migraine
pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients …

Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management

MB Russell, A Ducros - The Lancet Neurology, 2011 - thelancet.com
Hemiplegic migraine is a rare form of migraine with aura that involves motor aura
(weakness). This type of migraine can occur as a sporadic or a familial disorder. Familial …

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Molecular mechanisms of migraine: Nitric oxide synthase and neuropeptides

N Karsan, H Gosalia, PJ Goadsby - International Journal of Molecular …, 2023 - mdpi.com
Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …

Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

C Demartini, R Greco, AM Zanaboni, G Sances… - Progress in …, 2019 - Elsevier
Migraine is a disease for which there is still no defined pathophysiological etiology and few
translational models. The organic nitrate nitroglycerin has been in use as an experimental …

Neurovascular mechanisms of migraine and cluster headache

J Hoffmann, SM Baca… - Journal of Cerebral Blood …, 2019 - journals.sagepub.com
Vascular theories of migraine and cluster headache have dominated for many years the
pathobiological concept of these disorders. This view is supported by observations that …

Nitroglycerin as a model of migraine: Clinical and preclinical review

P Sureda-Gibert, M Romero-Reyes, S Akerman - Neurobiology of Pain, 2022 - Elsevier
Migraine stands as one of the most disabling neurological conditions worldwide. It is a
disorder of great challenge to study given its heterogeneous representation, cyclic nature …

Are some patient-perceived migraine triggers simply early manifestations of the attack?

N Karsan, P Bose, J Newman, PJ Goadsby - Journal of neurology, 2021 - Springer
Objective To study the agreement between self-reported trigger factors and early
premonitory symptoms amongst a group of migraineurs in both spontaneous and …