Oxidative and genotoxic damages in plants in response to heavy metal stress and maintenance of genome stability

S Dutta, M Mitra, P Agarwal, K Mahapatra… - Plant signaling & …, 2018 - Taylor & Francis
Plants, being sessile in nature, are constantly exposed to various environmental stresses,
such as solar UV radiations, soil salinity, drought and desiccation, rehydration, low and high …

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium

Y Chervona, A Arita, M Costa - Metallomics, 2012 - academic.oup.com
Carcinogenic metals, such as nickel, arsenic, and chromium, are widespread environmental
and occupational pollutants. Chronic exposure to these metals has been connected with …

Oxidative stress alters global histone modification and DNA methylation

Y Niu, TL DesMarais, Z Tong, Y Yao, M Costa - Free Radical Biology and …, 2015 - Elsevier
The JmjC domain-containing histone demethylases can remove histone lysine methylation
and thereby regulate gene expression. The JmjC domain uses iron Fe (II) and α …

Epigenetic regulation in chromium-, nickel-and cadmium-induced carcinogenesis

L Zhao, R Islam, Y Wang, X Zhang, LZ Liu - Cancers, 2022 - mdpi.com
Simple Summary Environmental and occupational exposure to heavy metals are risk factors
for cancers. However, the molecular mechanisms of how heavy metals induce …

[图书][B] DNA damage, DNA repair and cancer

C Bernstein, AR Prasad, V Nfonsam, H Bernstein - 2013 - books.google.com
DNA damage appears to be a fundamental problem for life. In this chapter we review evi‐-
dence indicating that DNA damages are a major primary cause of cancer. DNA damages …

The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not?

NB Aquino, MB Sevigny, J Sabangan… - … Science and Health …, 2012 - Taylor & Francis
During the past half-century, incidences of breast cancer have increased globally. Various
factors—genetic and environmental—have been implicated in the initiation and progression …

Thyroid disrupting effects of multiple metals exposure: Comprehensive investigation from the thyroid parenchyma to hormonal function in a prospective cohort study

A Li, Q Zhou, Y Mei, J Zhao, M Zhao, J Xu, X Ge… - Journal of Hazardous …, 2023 - Elsevier
This study aimed to investigate the thyroid disrupting effects of multiple metals exposure with
comprehensive investigation from the thyroid parenchyma to hormonal function. In this …

[HTML][HTML] Epigenetic mechanisms in metal carcinogenesis

L Manić, D Wallace, PU Onganer, YM Taalab… - Toxicology Reports, 2022 - Elsevier
Many metals exhibit genotoxic and/or carcinogenic effects. These toxic metals can be found
ubiquitously–in drinking water, food, air, general use products, in everyday and occupational …

CpG Site–Specific Hypermethylation of p16INK4α in Peripheral Blood Lymphocytes of PAH-Exposed Workers

P Yang, J Ma, B Zhang, H Duan, Z He, J Zeng… - … , biomarkers & prevention, 2012 - AACR
Background: Sufficient epidemiologic evidence shows an etiologic link between polycyclic
aromatic hydrocarbons (PAH) exposure and lung cancer risk. While the genetic …

Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature

C Liu, J Xu, Y Chen, X Guo, Y Zheng, Q Wang… - Environmental …, 2015 - Springer
Background Current studies of environmental health suggest a link between air pollution
components, such as particulate matter (PM), and various diseases. However, the specific …