RNA polymerase II C-terminal domain: tethering transcription to transcript and template
JL Corden - Chemical reviews, 2013 - ACS Publications
By definition the CTD consists of the amino acid sequences extending from the largest
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
Cell cycle-dependent transcription: the cyclin dependent kinase Cdk1 is a direct regulator of basal transcription machineries
JM Enserink, P Chymkowitch - International Journal of Molecular …, 2022 - mdpi.com
The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the
cell cycle. It phosphorylates several key proteins to control progression through the different …
cell cycle. It phosphorylates several key proteins to control progression through the different …
G1 cyclin–Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II
Cell division is thought to be initiated by cyclin-dependent kinases (Cdks) inactivating key
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …
Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …
Cell-cycle dependence of transcription dominates noise in gene expression
CJ Zopf, K Quinn, J Zeidman… - PLoS computational …, 2013 - journals.plos.org
The large variability in mRNA and protein levels found from both static and dynamic
measurements in single cells has been largely attributed to random periods of transcription …
measurements in single cells has been largely attributed to random periods of transcription …
The writers, readers, and functions of the RNA polymerase II C-terminal domain code
Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing
A Denoth-Lippuner, MK Krzyzanowski, C Stober… - Elife, 2014 - elifesciences.org
In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known
about how cells react to them. In yeast, partitioning of such circles to the mother cell at …
about how cells react to them. In yeast, partitioning of such circles to the mother cell at …
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
L Ramos-Alonso, P Holland… - Proceedings of the …, 2023 - National Acad Sciences
Mitotic entry correlates with the condensation of the chromosomes, changes in histone
modifications, exclusion of transcription factors from DNA, and the broad downregulation of …
modifications, exclusion of transcription factors from DNA, and the broad downregulation of …
Pathway connectivity and signaling coordination in the yeast stress‐activated signaling network
Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet
knowledge of the complete stress‐activated regulatory network as well as design principles …
knowledge of the complete stress‐activated regulatory network as well as design principles …
Engineered covalent inactivation of TFIIH-kinase reveals an elongation checkpoint and results in widespread mRNA stabilization
JB Rodríguez-Molina, SC Tseng, SP Simonett… - Molecular cell, 2016 - cell.com
During transcription initiation, the TFIIH-kinase Kin28/Cdk7 marks RNA polymerase II (Pol II)
by phosphorylating the C-terminal domain (CTD) of its largest subunit. Here we describe a …
by phosphorylating the C-terminal domain (CTD) of its largest subunit. Here we describe a …