Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

It is generally accepted that the functional compartmentalization of eukaryotic cells is
reflected by the differential occurrence of proteins in their compartments. The location and …

Fluorescence technology is fully entrenched in all aspects of biological research. To a
significant extent, future advances in biology and medicine depend on the advances in the …

This paper presents a review of imaging techniques and of their utility in system biology.
During the last decade systems biology has matured into a distinct field and imaging has …

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in
families with autosomal dominant late-onset Parkinson disease (PD). The LRRK2 protein …

Illumination plays an important role in optical microscopy. Köhler illumination, introduced
more than a century ago, has been the backbone of optical microscopes. The last few …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

The past decade has seen an unprecedented data explosion in biology. It has become
evident that in order to take full advantage of the potential wealth of information hidden in the …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Quantitative analysis of biological image data generally involves the detection of many
subresolution spots. Especially in live cell imaging, for which fluorescence microscopy is …