Helicobacter pylori Infection: Current Status and Future Prospects on Diagnostic, Therapeutic and Control Challenges

A Elbehiry, E Marzouk, M Aldubaib, A Abalkhail… - Antibiotics, 2023 - mdpi.com
Helicobacter pylori (H. pylori) infection, which affects approximately half of the world's
population, remains a serious public health problem. As H. pylori infection leads to a number …

Virulence of Helicobacter pylori outer membrane proteins: an updated review

C Xu, DM Soyfoo, Y Wu, S Xu - European Journal of Clinical Microbiology …, 2020 - Springer
Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as
gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H …

Helicobacter pylori BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development

D Doohan, YAA Rezkitha, LA Waskito, Y Yamaoka… - Toxins, 2021 - mdpi.com
Helicobacter pylori is a pathogenic microorganism that successfully inhabits the human
stomach, colonizing it by producing several virulence factors responsible for preventing host …

Pathogenesis of Helicobacter pylori Infection

S Backert, M Clyne - Helicobacter, 2011 - Wiley Online Library
Helicobacter pylori infections and clinical outcome are dependent on sophisticated
interactions between the bacteria and its host. Crucial bacterial factors associated with …

Helicobacter pylori adapts to chronic infection and gastric disease via pH-responsive BabA-mediated adherence

JA Bugaytsova, O Björnham, YA Chernov… - Cell host & …, 2017 - cell.com
The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood
group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive …

Polyionic tags as enhancers of protein solubility in recombinant protein expression

V Paraskevopoulou, FH Falcone - Microorganisms, 2018 - mdpi.com
Since the introduction of recombinant protein expression in the second half of the 1970s, the
growth of the biopharmaceutical field has been rapid and protein therapeutics has come to …

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

K Moonens, Y Hamway, M Neddermann… - The EMBO …, 2018 - embopress.org
The human gastric pathogen Helicobacter pylori is a major causative agent of gastritis,
peptic ulcer disease, and gastric cancer. As part of its adhesive lifestyle, the bacterium …

Structural insights into polymorphic ABO glycan binding by Helicobacter pylori

K Moonens, P Gideonsson, S Subedi, J Bugaytsova… - Cell host & …, 2016 - cell.com
Summary The Helicobacter pylori adhesin BabA binds mucosal ABO/Le b blood group (bg)
carbohydrates. BabA facilitates bacterial attachment to gastric surfaces, increasing strain …

Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role

R Matos, I Amorim, A Magalhães… - Frontiers in molecular …, 2021 - frontiersin.org
Helicobacter species infections may be associated with the development of gastric
disorders, such as gastritis, peptic ulcers, intestinal metaplasia, dysplasia and gastric …

Biologic roles of the ABH and Lewis histo‐blood group antigens part I: infection and immunity

CP Stowell, SR Stowell - Vox sanguinis, 2019 - Wiley Online Library
The ABH and Lewis antigens were among the first of the human red blood cell
polymorphisms to be identified and, in the case of the former, play a dominant role in …